Once I got my white truck, I felt crippled without the feedback you can get from the aftermarket ECU. The OEM ECU had issues, so I picked up a PxS for it. In my red truck, I converted to sequential, so it was a bit of extra effort. I left this one bank-to-bank, so the install was really nothing at all - move 3 wires in the harness. I added the Perfect Tuning gauge, fuel and oil pressure senders, and I have great insight into what the driveline is doing.
Now I just progressively change things and tweak the tune a little. 60 lb injectors, no sweat. Little roller cam, piece of cake. Surge tank fuel system, just a few changes due to more stable fuel pressure.
I had used a TwEECer RT with a datalogging wideband for years in the past. Capturing the mass air reading with the WBO2 feedback, I was able to tune it pretty decently. But comparing that to the flexibility and amount of data I can get from the PxS is like comparing reading glasses and a microscope.